Plas-Free’s Ammonia Adsorption Plasma Column (AAPC-300) device is a non-pyrogenic, sterile, single-use device designed to remove ammonia from the blood stream. The AAPC-300 effectively and specifically extracts ammonia from plasma fraction, thus enabling the reduction of ammonia levels during hepatic encephalopathy (HE).  Neurological injury is non-reversible, thus time is critical in the treatment of hyperammonemia. The APPC-300 can reduce the levels of ammonia in less than 1.5 hours thereby preventing significant accumulated neurologic injury. This contrasts with the pharmacokinetics of drugs that can take few hours and subsequently cause additional neurologic injury.