{"id":1145,"date":"2023-12-23T18:54:42","date_gmt":"2023-12-23T18:54:42","guid":{"rendered":"https:\/\/transindiamedicare.com\/?page_id=1145"},"modified":"2023-12-24T18:35:01","modified_gmt":"2023-12-24T18:35:01","slug":"clearplasma","status":"publish","type":"page","link":"https:\/\/transindiamedicare.com\/index.php\/clearplasma\/","title":{"rendered":"Clearplasma"},"content":{"rendered":"\n
\"\"<\/figure>\n\n\n\n

CLEARPLASMA<\/h2>\n\n\n\n
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Plas-Free<\/strong> has developed ClearPlasma, an innovative filtration system that modifies human plasma to improve the treatment of massive bleeding. By extracting plasminogen, an important protein responsible for dissolving blood clots, ClearPlasma\u2122 enhances coagulation and favours haemostasis. ClearPlasma\u2122 transforms blood plasma through a sophisticated filtration method based on chemical adhesion.<\/p>\n\n\n\n

\u200b<\/p>\n\n\n\n

ClearPlasma\u2122 is a disposable filter that can be used  either in the patient bedside (on line) or as part of the plasma preparation (off line), thus not affecting common clinical practices. ClearPlasma\u2122 safety has been proven by pre-clinical and clinical studies in accordance to the regulatory pathways. <\/p>\n<\/div><\/div>\n\n\n\n

VALUE PROPOSITION:<\/h2><\/div>\n\n\n\n
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Decrease of 55%<\/strong> bleeding.<\/strong><\/h4><\/div>
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By efficiently removing fibrinolytic proteins such plasminogen, ClearPlasma\u2122 decreases the activity of the endogenous fibrinolytic system and increases the efficiency of coagulation.  Patients transfused with plasminogen-free plasma will show an increased capacity to form stable haemostaic clots, thus reduced bleeding tendency thus potentially saving more lives.<\/p><\/div><\/div>\n<\/div>\n\n\n\n

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Affordable cost<\/strong><\/h3><\/div>
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Plas-Free clinical data show that ClearPlasma\u2122 can reduce significantly the number of platelets units needed during excessive bleeding. Improving the clinical outcome and reducing costs and subsequently reducing hospitalization duration. Moreover, the use of ClearPlasma can prevent certain expensive corrective measures, such as antifibrinolytic therapy, that may be required after standard plasma transfusion.<\/p><\/div><\/div>\n<\/div>\n\n\n\n

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It is safe.<\/strong><\/h3><\/div>
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ClearPlasma\u2122 significantly reduces the concentration of plasminogen, without altering other coagulation parameters. Importantly, no thromboembolic or other adverse events were found in human trials. <\/p><\/div><\/div>\n<\/div>\n\n\n\n

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Easy to use.<\/strong><\/h3><\/div>
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ClearPlasma\u2122 can be integrated into current practices of plasma bag transfusion causing minimal distress to the patients. Transfusion time is not affected by the filtration process, and no extra training is needed for physicians. The device can be used on the bedside of the patients and\/or in the blood bank.  <\/p><\/div><\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n

TRANSFUSION SYSTEM<\/h2><\/div>\n\n\n\n
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TRANSFUSION SYSTEM<\/h2><\/div>\n\n\n\n
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Main advantages of the solution with respect to competing solutions: <\/strong>No other competitor offers a solution containing coagulation factors but fibrinolytic factors-free. Currently, Fresh frozen plasma (FFP) is the main treatment of bleeding disorders. Although FFP is relatively cheap and safe to use, it often fails to halt bleeding due to the presence of components of fibrinolytic cascade. To address this problem, antifibrinolytic therapy using Tranexamic acid    (TXA) have been used. However, these therapies have shown several main disadvantages such as their effectiveness is limited to the first 3 hours and more importantly, post and arterial thrombotic events. <\/p>\n\n\n\n

\"Presentation1.png\"<\/figure>\n\n\n\n

rFVIIa – <\/strong>Recombinant activated clotting factor VII<\/p>\n\n\n\n

Finally, rFVIIa is an expensive but potent procoagulant used mainly in treating haemophilia. Unlike ClearPlasma, rFVIIa does not induce the inhibition of the fibrinolytic activity. Moreover, it causes side-effects like increasing the rate of thromboembolic events in intracranial hemorrhage and cardiac surgery[i]. See the table below showing the performance of ClearPlasma vs competing solutions.<\/p>\n\n\n\n

Unique selling proposition:<\/strong>\u00a0ClearPlasma is a cost-effective, easy-to-use filtration system attachable to current Apheresis systems and plasma unit bags without changing the procedure’s duration or consuming physician’s attention. It is a new product that exhibits pro-coagulant and anti\/fibrinolytic properties at the same time that can effectively reduce bleeding (55%). ClearPlasma stops blood flow in bleeding patients, reducing the units of plasma needed during transfusion (45%) and hence reducing treatment costs and mortality.<\/p>\n\n\n\n

<\/p>\n<\/div><\/div>\n\n\n\n

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<\/p>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"

CLEARPLASMA Plas-Free has developed ClearPlasma, an innovative filtration system that modifies human plasma to improve the treatment of massive bleeding. By extracting plasminogen, an important protein responsible for dissolving blood clots, ClearPlasma\u2122 enhances coagulation and favours haemostasis. ClearPlasma\u2122 transforms blood plasma through a sophisticated filtration method based on chemical adhesion. \u200b ClearPlasma\u2122 is a disposable filter …<\/p>\n

Clearplasma<\/span> Read More »<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-1145","page","type-page","status-publish","hentry"],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"depicter-thumbnail":false},"uagb_author_info":{"display_name":"transindiamedicare.com","author_link":"https:\/\/transindiamedicare.com\/index.php\/author\/transindiamedicare-com\/"},"uagb_comment_info":0,"uagb_excerpt":"CLEARPLASMA Plas-Free has developed ClearPlasma, an innovative filtration system that modifies human plasma to improve the treatment of massive bleeding. By extracting plasminogen, an important protein responsible for dissolving blood clots, ClearPlasma\u2122 enhances coagulation and favours haemostasis. ClearPlasma\u2122 transforms blood plasma through a sophisticated filtration method based on chemical adhesion. \u200b ClearPlasma\u2122 is a disposable filter…","_links":{"self":[{"href":"https:\/\/transindiamedicare.com\/index.php\/wp-json\/wp\/v2\/pages\/1145","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/transindiamedicare.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/transindiamedicare.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/transindiamedicare.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/transindiamedicare.com\/index.php\/wp-json\/wp\/v2\/comments?post=1145"}],"version-history":[{"count":4,"href":"https:\/\/transindiamedicare.com\/index.php\/wp-json\/wp\/v2\/pages\/1145\/revisions"}],"predecessor-version":[{"id":1196,"href":"https:\/\/transindiamedicare.com\/index.php\/wp-json\/wp\/v2\/pages\/1145\/revisions\/1196"}],"wp:attachment":[{"href":"https:\/\/transindiamedicare.com\/index.php\/wp-json\/wp\/v2\/media?parent=1145"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}